Request PDF on ResearchGate | Determinación de la concentración de fosfatos en los colirios antiglaucomatosos comercializados en España | Objectives: To. Quitosana para liberação de fármacos antiglaucomatosos / Juçara. Ribeiro Franca. .. Figura 10 – Inserts oftálmicos para liberação prolongada de fármacos: (a). Categoría de Productos, Antialérgicos, Antibióticos, Antibióticos con Esteroides, Antiglaucomatosos, Antiinflamatorios Esteroides, Antiinflamatorios no.

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Therefore, we realized that the droplet volume of eyedrop is still considerably high, and that this leads to a waste of the product and increased cost to the manufacturer and the consumer. The IOP was measured at 8 am antiglaucoatosos effect and 2 and 8 hours after instillation.

In this case, we oftalmcios inclined to suggest that the patient try the generic. Viscosity-modifying agents increase drug contact time with the ocular surface, thus improving absorption.

The FDA 1 considers that: In the other brands, the droplet formed at 90o was bigger Graph 1. Basically, the FDA criterion for determining therapeutic equivalence is formulation equivalence.

In the absence of comparative studies between the brand-name and the generic medication, FDA classified the generic formulation of the timolol maleate gel forming solution Falcon Laboratories as ABalthough the products are formulated with different slow-release gel vehicles.

In the previous edition, the Brazilian Pharmacopeia defined that any measurement tool to administer liquid medicines must meet specific volumetric standards: According to the shape of the tip of the stopper and the surface tension of the liquid, there is a tendency of each vial producing a bigger or smaller drop when tilted than when it is inverted at 90o.

All medications, both brand-name and generic, showed a reduction in active ingredient concentration and BAK when exposed to temperatures above those in the information leaflet.


Both safety and vision recovery time were similar in both groups. Concentraciones de brimonidina en humor acuoso en el otfalmicos. Corneal complications associated with tropical ophthalmic use of nonsteroidal antiinflammatory drugs. Bearing in mind that an active ingredient is in balance between systemic circulation and the site of action, it is assumed that drug values in blood represent drug bioavailability.

Besides that, in relation to the vial tilt, we found out that there is antiglaucomatoos variation in the droplet volume, and there is a concern by manufacturers on this fact, since the directions of 12 out of the 13 brands tested fail to inform the consumer the correct way of instilling the eyedrop.

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Estacia P, Tognon T. We are concerned that neither the Brazilian nor the American Pharmacopoeia considers the eye continent antiiglaucomatosos for the production of eyedrops, and we understand that otfalmicos attention should be given to the production of droplets of smaller volume, so there is no waste or risk of increased systemic absorption of some drug. Bioavailability is assessed using pharmacokinetic parameters, including: In both groups, all patients showed week IOP values lower than 21 mmHg, i.

The exact nature of the particulate matter is unknown.

Are generics and brand-name medicines the same?*

Each vial of eyedrops was lightly pressed until a drop fell off from a height of 5. The dosage used in this study for antiglaucommatosos solutions was based on the way we usually prescribe these eyedrops in our service, also considering the fact that eyedrops with preservatives should not be used more frequently than 4 times a day, so that there is no damage to the eye surface.

Bottles of both generic medications had higher levels of particulate matter compared to brand-name versions.

In sum, several researchers 12,14 have noted different problems in generic prednisolone acetate formulations, which were associated with suspension characteristics and forming of precipitates.


He concludes that concerns about generic medications will only disappear when comparative studies with original medications are promoted and conducted for efficacy, safety and patient comfort. Dosage variability of topical ocular hypotensive products: Cantor 20 considers that when switching to a generic medicine, neither the patient not the physician can be sure that the new medicine will be well tolerated or effective.

Another factor that influences the volume of the drop is the slope of the dropper vial. This way, the average volume of each droplet was determined by the ratio between the mass of 1. No statistically significant differences were observed between both medications at 8 am, nor 2 hours after administration. Note that the percentage of the difference in the volume of the droplet is roughly the same as the difference in the number of droplets.

A class effect was considered Noecker and Simmons 19 state that “There is no doubt we are moving toward a totally generic world, and as our patients adapt to different medicines, we must monitor efficacy and safety vigilantly.

Farmacos Oftalmologicos by Naldo Jimenez on Prezi

Antilgaucomatosos, note that the current legislation does not bring the definition of determination of the droplet volume anymore, nor sets specific regulations for the droplet volume of eyedrops. Noecker and Simmons 19 adopt different positions according to the patient’s clinical status:.

FDA criteria for determining clinical efficacy in these medicines vary according to the pharmacological group and are based on parameters or measures used to establish the efficacy of the innovator drug.