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Pedoman Tata Laksana Klinis Flu Burung (H5N1) di. Rumah Sakit (AI Clinical Case Management Guideline for. Hospital). This Guideline serves as the primary . Pedoman Tata Laksana Klinis Flu Burung (H5N1) di Rumah Sakit (AI Clinical Case Management Guideline for Hospital). This Guideline serves as the primary . Petunjuk Umum Pencegahan Flu Burung (H5N1) Pada Unggas Dan Manuisa ( Risk Reduction Behaviors). Produced under the CBAIC project, this booklet.

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Tissue damage associated with pathogenic flu virus infection can ultimately result in death. Health Care and Laboratorian Guidance. The authors are grateful to Dr. Influenza A H5N1 virus, has spread to several countries in the world and has a high mortality rate.

Comprehensive research is required to determine the characteristics of the H5N1 antigenic virus that infects human beings in Indonesia, as well as to determine the changes in the antigenicity of the H5N1 virus. You will be subject to the destination website’s privacy policy when you follow the link. These burungg indicate that all anti-H5 antibodies can cross-react with the H5N1 virus strains used in this study.

People have reacted by buying less chicken, causing poultry sales and prices to fall. The immunity against influenza infection occurs via burunb that interact with viral surface proteins, that is, HA and Burungg. Meanwhile, the virus has evolved into several clades. This current deadly strain of H5N1 is unusual in being deadly to so many species, including some, like domestic cats, never previously susceptible to any influenza virus.

This drug has become a focus for some governments and organizations trying to prepare for a possible H5N1 pandemic. In MayNorth Korea confirmed a H5N1 bird flu outbreak burng forced authorities to kill overducks in Pyongyang. The preparation of the seven viruses was heat inactivated for the immunization of rabbits.

Highly Pathogenic Asian Avian Influenza A(H5N1) Virus

The reviewers reported no competing interests. Antigenic, Cross-reactivity, Antibody, H5N1. Influenza A viruses are generally highly susceptible to mutation, especially in the HA gene, and these mutations occur frequently and unpredictably.


Rare human-to-human spread with this virus has occurred, but it has fl been sustained and no community spread of this virus has ever been identified. The National Academies Press.

While H5N1 undergoes mutation and reassortment, creating variations which can infect species not previously known to carry the virus, not all of these variant forms can infect humans.

According to the World Health Organization and United Nations Food and Agriculture OrganizationH5N1 pathogenicity is gradually continuing to rise in endemic areas, but the avian influenza disease situation in farmed birds is being held in check by vaccination, and so far there is “no evidence of sustained human-to-human transmission” of the virus.

Asian H5N1 vaccine is being stockpiled for pandemic preparedness by the United States government. They also found evidence of what doctors had long suspected — the virus not only affects the lungs, but also passes throughout the body into the gastrointestinal tract, the brain, liver, and blood cells.

Archived PDF from the original on Webster published an article titled “The world is teetering on the edge of a pandemic that could kill a large fraction of the human population” in American Scientist.

Find articles by Amin Soebandrio. Published online Aug Innew isolates of H5N1 were appearing within the bird vlu of Hong Kong. After sequencing the HA gene and analyzing the phylogenetic tree, it can be observed that all seven viruses are from clade 2.

Influenza A virus subtype H5N1 – Wikipedia

Please review our privacy policy. The characteristics of the H5N1 are similar to the characteristics of some common influenza viruses that continuously change their antigenicity to avoid the host immune response fou are related to antigenic drift and antigenic shift.

H5N1 is easily transmissible between birds, facilitating a potential global spread of H5N1. The sera were treated by using a receptor-destroying enzyme Denka Saiken Co. Humans with H5N1 have typically caught budung from chickens, which were in turn infected by other poultry or waterfowl.

Ondri Dwi Sampurno, Prof. Isolation and characterization of virus “. While cellular immune responses maybe contribute effectively to eradicate cells infected by fu virus is not analyze in this study.

Sporadic human infections with Asian H5N1 virus have occurred in other countries, primarily in Asia and Africa. Based on the results of the phylogenetic analysis and the cross reactivity analysis, it is known that viruses in the same subclade can stimulate different immune responses.


Influenza A virus subtype H5N1

Most human infections with Asian H5N1 viruses in other countries have occurred after prolonged and close contact with infected sick or dead birds. No one knows if these or other symptoms will be the symptoms of a humanized H5N1 flu. In Arctic temperatures, it does not degrade at all. Clinical signs of H5N1 in birds range from mild – decrease in egg production, nasal discharge, coughing and sneezing – to severe, including loss of coordination, energy, and appetite; soft-shelled or misshapen eggs; purple discoloration of the wattles, head, eyelids, combs, and hocks; and diarrhea.

The phylogenetic tree of the clade of Indonesian strain viruses. The report stated the virus may sometimes stick to surfaces or get kicked up in fertilizer dust to infect people.

Antigenic Variation in H5N1 clade Viruses in Indonesia From to

The immune response will protect the host against reinfection h5n11 the same virus or an antigenically similar viral strain. H5N1 has mutated into a variety of strains with differing pathogenic profiles, some pathogenic to one species but not others, some pathogenic to multiple species. Thus, it appears that the antigenicity of the H5N1 virus has changed. Proceedings of the National Academy of Sciences. Table 3 shows that the HI test for the anti-H5N1 antibodies demonstrated cross-reactions with the seven strains that were used in this study.

Research has shown that a highly contagious strain of H5N1, one that might allow airborne transmission between mammals, can be reached in only a few mutations, raising concerns about a pandemic and bioterrorism. Archived from the original on April 14, This study shows that the H5N1 strains isolated from Indonesians from to are members of the same clade, 2.