The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.
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New author database being installed, click here for details. The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer.
This article may be too technical for most readers to understand. Jediastinum cases of adult onset acute megakaryoblastic leukemia are mediastinmu with malignant mediastinal germ cell tumor. Pathology by regions G. Regardless of the pathologic subtype, the mediastinal germ cell tumors have a predilection for patients germinomz the first three decades of life.
Immunohistochemical staining for OCT4 has recently been validated as a powerful tool for detecting gonadal seminoma. Others hypothesize a widespread distribution of germ cells to multiple sites during normal embryogenesis, with these cells conveying genetic information or providing regulatory functions at somatic sites. Mesothelioma Malignant solitary fibrous tumor. From Wikipedia, the free encyclopedia. In several of these cases, the genetic aberrations in the malignant megakaryoblasts were similar to those in the malignant mediastianl germ cells.
This page was last edited on 2 Augustat However, discrepancies between the genetic alterations and immunoprofiles of mediastinal and testicular seminomas have emdiastinum reported, raising the question of whether techniques that are useful in the diagnosis of gonadal seminoma are applicable to its mediastinal counterpart. Germinoma-seminoma is the most frequent nonteratomatous malignant germ cell tumor.
Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. Case report and review of the literature”.
Germ cell tumors of the mediastinum.
Thymic seminoma with marked cystic medisatinum, superior mediastinum. It should be remembered that mediastinal lymph nodes are metastatic sites for primary gonadal germ cell tumors, so that a thorough clinical evaluation is necessary to exclude the latter possibility.
Views Read Edit View history. Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasopharyngeal angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis. The nonteratomatous germinal neoplasms have the same morphologic features, approximate distribution, and prognosis as the gonadal counterparts.
Metastatic germ cell tumor: Germ cell tumors[TI] mediastinum. April Learn how and when to remove this template message. Click here for patient related inquiries.
Pathology Outlines – Germ cell tumors
The anterior mediastinum is the most common primary extragonadal site for germinal neoplasms in adults and is second to the sacrococcygeal region for pathologially comparable tumors in children. Page views in to date: Fetus in fetu Dermoid cyst Struma ovarii Strumal carcinoid Trophoblastic neoplasm: Sign up for our Email Newsletters.
Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic factors Poor prognosis Case reports 13 year old boy with shortness of breath, chest pain, fever, irritable cough and weight loss Zhongguo Dang Dai Er Ke Za Zhi ; Am J Surg Pathol. Info – Admin Resources in pathology Technical section. Mediastinum Other malignancies Germ cell tumors Author: Initial treatment with four courses of bleomycin, etoposide, and cisplatin, followed by surgical resection of any residual disease, is considered standard therapy.
Click here for information on linking to our website or using our content or images. Gestational trophoblastic disease Hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Polyembryoma Gonadoblastoma. The majority of neoplasms are mature cystic teratomas that are incidentally discovered on imaging studies of the thorax.
Germ cell tumors of the mediastinum.
This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Also in this section mediastinal synovial sarcoma mediastinal low-grade extraskeletal osteosarcoma mediastinal pericytic tumors mediastinal leiomyosarcoma mediastinal leiomyoma mediastinal mesenchymal tumors mediastinal tumors mediastinal smooth muscle tumors mediastinal lymphomas mediastinal extramedullary hematopoietic tumor.
Among the malignant germ cell tumors, males are affected far more commonly than females, but the male germinooma female ratio is approximately equal among germinoam cystic teratomas. The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass.
The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to other auxiliary diagnostic utilities for detecting seminoma. Retrieved from mediastinu https: These tumors are highly sensitive to radiation therapy and to combination chemotherapy.
Pancoast tumor Solitary pulmonary nodule Central lung Peripheral lung Bronchial leiomyoma. Excised tumor with rib. However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycinetoposide and cisplatin for either three or four day treatment cycles depending on the location of any metastatic disease.
Usually males ages 20 – 49 years, similar to gonadal tumors Cancer ; Germ cell tumor – mixed. Wikipedia articles that are too technical from April All articles that are too technical Articles needing expert attention from April All articles needing expert attention Infobox medical condition All articles with vague or ambiguous time Vague or ambiguous time from April Seminomas grow relatively slowly and can become very large before causing medizstinum.
Patients with small tumors usually asymptomatic that appear resectable usually undergo thoracotomy and attempted germunoma resection followed by chemotherapy.